Reversible Thyroid Nodule in Van Wyk–Grumbach Syndrome: An Unusual Case Report

Laila A. AlBishi · 2026

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Description

Laila AlBishi reports a young girl whose thyroid lump shrank away once her hormone lack was treated, in a 2026 case report. The child had Van Wyk-Grumbach syndrome, a rare result of long-untreated low thyroid function in children, marked by early puberty signs despite the hormone lack. The six-year-old Saudi girl had vaginal bleeding and months of breast development, and doctors felt a lump on the right side of her thyroid.

Tests showed severe thyroid failure, high prolactin, delayed bone age, cystic ovaries, and a swollen pituitary gland. On thyroid hormone pills, her levels settled and the lump, gland swelling, and cysts all shrank while her growth improved. The author notes this reversible lump as a first for the syndrome.

Catalog record

CREATORLaila A. AlBishi
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE24 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC13661090

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