Finger-actuated microfluidic device for point-of-care circulating cell-free nucleic acid extraction
Ghulam Musaddaq, Labibah Ehsan, Yano Yoga, Joshua Castillo, Linda Marriott, Nicholas R. Leslie, Deborah Williamson, Thomas Tran, Chuan Kok Lim, Maïwenn Kersaudy-Kerhoas · 2026
Read Finger-actuated microfluidic device for point-of-care circulating cell-free nucleic acid extraction by Ghulam Musaddaq, Labibah Ehsan, Yano Yoga, Joshua Castillo, Linda Marriott, Nicholas R. Leslie, Deborah Williamson, Thomas Tran, Chuan Kok Lim, Maïwenn Kersaudy-Kerhoas (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13660751.txt.
Description
Ghulam Musaddaq and co-authors build a finger-powered chip that extracts genetic material at the bedside, in a 2026 paper. Tests for infection or cancer often start by pulling tiny amounts of free DNA and RNA from blood plasma. That prep step is the bottleneck for point-of-care testing, since it usually needs a lab, power, and pipettes.
Their device replaces pumps and plugs with finger presses: valves, a pump, and blister packs of reagents all work by hand. The full routine — break cells, bind, wash, release — takes about thirty-five minutes. On spiked samples it recovered about eighty-five percent of the DNA, rivaling bench kits and a robot system. Power-free prep could bring molecular tests to clinics off the grid.
Catalog record
| CREATOR | Ghulam Musaddaq, Labibah Ehsan, Yano Yoga, Joshua Castillo, Linda Marriott, Nicholas R. Leslie, Deborah Williamson, Thomas Tran, Chuan Kok Lim, Maïwenn Kersaudy-Kerhoas |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |