Atractylenolide III attenuates age-related vertebral bone loss by suppressing macrophage inflammation and osteoclastogenesis
Cheng Xiang, Wenyuan Xiang, Jannatul Ferdus Shila, Atikul Islam, Yilin Liao, Zhengxiao Ouyang, Gen Wu, Xinfeng Gao · 2026
Read Atractylenolide III attenuates age-related vertebral bone loss by suppressing macrophage inflammation and osteoclastogenesis by Cheng Xiang, Wenyuan Xiang, Jannatul Ferdus Shila, Atikul Islam, Yilin Liao, Zhengxiao Ouyang, Gen Wu, Xinfeng Gao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13659678.txt.
Description
Cheng Xiang and co-authors test a plant compound against age linked bone loss in a 2026 study. As mice and people age, swelling in bone marrow stirs up cells that eat bone. The compound comes from a plant used in traditional remedies and is known to calm swelling. The team asked whether it can guard the spine bones of old mice.
Aged marrow held more swelling signals in immune cells than young marrow did. In lab tests, the compound cut those signals and slowed the forming of bone eating cells. Old mice treated for a month showed stronger spine bone structure. They also had more bone building surface and fewer bone eating cells, with no clear harm to body weight.
Catalog record
| CREATOR | Cheng Xiang, Wenyuan Xiang, Jannatul Ferdus Shila, Atikul Islam, Yilin Liao, Zhengxiao Ouyang, Gen Wu, Xinfeng Gao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |