PTTG1 drives intestinal-type gastric cancer progression via G2/M checkpoint-mediated cell-cycle reprogramming
Caihong Hu, Lijun Bian, Lin Luo, Zhonghua Zheng, Yuheng Chen, Xinxiang Gao, Fengyuan Li, Dinghua Yang, Yao Liu, Gang Li, Hao Xu, Caiwang Yan, Guangfu Jin · 2026
Read PTTG1 drives intestinal-type gastric cancer progression via G2/M checkpoint-mediated cell-cycle reprogramming by Caihong Hu, Lijun Bian, Lin Luo, Zhonghua Zheng, Yuheng Chen, Xinxiang Gao, Fengyuan Li, Dinghua Yang, Yao Liu, Gang Li, Hao Xu, Caiwang Yan, Guangfu Jin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13659674.txt.
Description
Intestinal-type stomach cancer creeps forward through a known sequence of tissue changes, but the drivers of each step are fuzzy. Caihong Hu and co-authors sequenced single cells from matched normal, precancerous, and tumor tissue in five patients. A transitional cell type swelled along the path to cancer, and one gene kept climbing with it: PTTG1.
Silencing the gene in cancer cells broke their cycle control and slowed growth, spread, and invasion. Forcing it higher made organoids grow faster and shifted their mucus traits. In mice, tumors without the gene grew poorly. The 2026 study nominates PTTG1 as both a warning marker and a drug target for this cancer.
Catalog record
| CREATOR | Caihong Hu, Lijun Bian, Lin Luo, Zhonghua Zheng, Yuheng Chen, Xinxiang Gao, Fengyuan Li, Dinghua Yang, Yao Liu, Gang Li, Hao Xu, Caiwang Yan, Guangfu Jin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |