Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis
Apisit Kaewsanit, Aime Luna, Bradley Judge, Nicole Shelley, Karl Friedrichsen, Jayashree Rajamanickam, Zhude Tu, Yong Wang, Tammie L S Benzinger, Qing Wang, Matthew R Brier · 2026
Read Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis by Apisit Kaewsanit, Aime Luna, Bradley Judge, Nicole Shelley, Karl Friedrichsen, Jayashree Rajamanickam, Zhude Tu, Yong Wang, Tammie L S Benzinger, Qing Wang, Matthew R Brier (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13659309.txt.
Description
Apisit Kaewsanit and co-authors apply an advanced MRI method in multiple sclerosis in a 2026 study. Standard MRI cannot untangle the mixed tissue changes inside MS lesions. The new method splits the diffusion signal into parts tied to fibers, cells, and open space. The team asked how those parts differ by disease stage and shift with early treatment.
Untreated relapsing patients showed weaker fiber signal in normal looking white matter than controls. Lesions held lower fiber and cell shares and more open space than nearby tissue. After three months of strong treatment, lesion fiber share rose while cell shares fell. Clusters of lesions formed repeatable subtypes from the three measures.
Catalog record
| CREATOR | Apisit Kaewsanit, Aime Luna, Bradley Judge, Nicole Shelley, Karl Friedrichsen, Jayashree Rajamanickam, Zhude Tu, Yong Wang, Tammie L S Benzinger, Qing Wang, Matthew R Brier |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |