The Tumor Microenvironment Score and Its Subsite-Specific Relevance in Colon Cancer
Mari J. Jawad, Vilja V. Tapiainen, Ville K. Äijälä, Päivi H. Sirniö, Anne E. Tuomisto, Hanna Elomaa, Maarit Ahtiainen, Olli Helminen, Erkki-Ville Wirta, Toni T. Seppälä, Jan Böhm, Jukka-Pekka Mecklin, Henna Karjalainen, Meeri Kastinen, Timo Väisänen, Vesa-Matti J. Pohjanen, Markus J. Mäkinen, Jukka · 2026
Read The Tumor Microenvironment Score and Its Subsite-Specific Relevance in Colon Cancer by Mari J. Jawad, Vilja V. Tapiainen, Ville K. Äijälä, Päivi H. Sirniö, Anne E. Tuomisto, Hanna Elomaa, Maarit Ahtiainen, Olli Helminen, Erkki-Ville Wirta, Toni T. Seppälä, Jan Böhm, Jukka-Pekka Mecklin, Henna Karjalainen, Meeri Kastinen, Timo Väisänen, Vesa-Matti J. Pohjanen, Markus J. Mäkinen, Jukka (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13657390.txt.
Description
Mari Jawad and a large team of colleagues validate a combined tissue score for predicting colon cancer survival, checking whether it behaves differently on the right and left sides of the colon. The Tumor Microenvironment Score merges immune reaction grade, stroma percentage, and tumor budding into four groups. Two retrospective cohorts totaling over fifteen hundred patients were scored from standard stained slides.
Higher scores meant worse five-year disease-specific survival on both sides. In adjusted analysis the highest score roughly tripled risk in the first cohort. Validation showed a stronger effect in right-sided tumors. The score also stratified better than an earlier two-component version. The authors propose it as an integrative prognostic marker, especially for right-sided disease.
Catalog record
| CREATOR | Mari J. Jawad, Vilja V. Tapiainen, Ville K. Äijälä, Päivi H. Sirniö, Anne E. Tuomisto, Hanna Elomaa, Maarit Ahtiainen, Olli Helminen, Erkki-Ville Wirta, Toni T. Seppälä, Jan Böhm, Jukka-Pekka Mecklin, Henna Karjalainen, Meeri Kastinen, Timo Väisänen, Vesa-Matti J. Pohjanen, Markus J. Mäkinen, Jukka |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |