Native amniotic fluid promotes barrier-associated maturation of the neonatal intestine under physiological conditions
Fredy John Makele, Chenang Sheng, Jiayi Wu, Yixin Zhang, Tianci Weng, Yuchen Zhang, Yi Yang, Wenqiang Zhang, Libin Zhu · 2026
Read Native amniotic fluid promotes barrier-associated maturation of the neonatal intestine under physiological conditions by Fredy John Makele, Chenang Sheng, Jiayi Wu, Yixin Zhang, Tianci Weng, Yuchen Zhang, Yi Yang, Wenqiang Zhang, Libin Zhu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13655869.txt.
Description
Makele and co-authors test whether the fluid that surrounds a baby before birth helps the newborn gut mature. The fluid holds many active compounds that reach the fetal gut. After birth, the gut lining must seal itself into a firm barrier fast.
The team used two kinds of lab-grown gut cells and a newborn rat model. They applied the natural fluid at two strengths and measured the sealing proteins that join gut cells. They also checked how well the cell layers blocked leaks. The work was done under normal, non-injury conditions, to test growth support rather than repair. The results speak to how the fluid may ready the gut for feeding after birth. That role could inform care for fragile newborns.
Catalog record
| CREATOR | Fredy John Makele, Chenang Sheng, Jiayi Wu, Yixin Zhang, Tianci Weng, Yuchen Zhang, Yi Yang, Wenqiang Zhang, Libin Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |