Cadherin-26 Promotes Airway Remodeling via Stabilizing Epithelial Expression of the Epidermal Growth Factor Receptor in Asthma
Jiali Gao, Gongqi Chen, Chunli Huang, Zhen Wang, Wei Gu, Huiru Jie, Tiantian Xiong, Yuchen Feng, Lingling Yi, Dan Cheng, Guohua Zhen · 2026
Read Cadherin-26 Promotes Airway Remodeling via Stabilizing Epithelial Expression of the Epidermal Growth Factor Receptor in Asthma by Jiali Gao, Gongqi Chen, Chunli Huang, Zhen Wang, Wei Gu, Huiru Jie, Tiantian Xiong, Yuchen Feng, Lingling Yi, Dan Cheng, Guohua Zhen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13655397.txt.
Description
Lung researchers in China find a grip protein that helps drive airway reshaping in asthma. In asthma, the airway wall thickens and stiffens over time, a change called remodeling. A growth signal on airway skin cells is known to drive that change by flipping cells to a scar-like state. What sets the level of that signal dock was not clear. The team pinned it on cadherin-26, a grip protein rich in airway skin.
Levels of the protein in patient airway samples tracked with wall base thickness. Mice that lacked its gene showed far less airway twitch and reshaping under dust mite stress. In lab airway cells, cutting the protein blocked the scar-like flip, while adding it sped the flip. The protein holds the growth dock steady on the cell surface. Blocking that grip is a fresh drug idea.
Catalog record
| CREATOR | Jiali Gao, Gongqi Chen, Chunli Huang, Zhen Wang, Wei Gu, Huiru Jie, Tiantian Xiong, Yuchen Feng, Lingling Yi, Dan Cheng, Guohua Zhen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |