Frailty and Bleeding Events in Heart Failure: Insights from the JROADHF-NEXT
Taisuke Nakade, Yudai Fujimoto, Tomomi Ide, Keisuke Kida, Shouji Matsushima, Hidetaka Kaku, Nobuyuki Enzan, Masataka Ikeda, Takeshi Kitai, Tatsunori Taniguchi, Takahiro Okumura, Takeshi Tohyama, Hiroyuki Tsutsui, Yuya Matsue · 2026
Read Frailty and Bleeding Events in Heart Failure: Insights from the JROADHF-NEXT by Taisuke Nakade, Yudai Fujimoto, Tomomi Ide, Keisuke Kida, Shouji Matsushima, Hidetaka Kaku, Nobuyuki Enzan, Masataka Ikeda, Takeshi Kitai, Tatsunori Taniguchi, Takahiro Okumura, Takeshi Tohyama, Hiroyuki Tsutsui, Yuya Matsue (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13654389.txt.
Description
Taisuke Nakade and thirteen colleagues use a large Japanese heart failure registry to ask whether frailty raises the risk of bleeding. Frail patients are widely assumed to bleed more easily, especially on blood-thinning drugs, yet direct evidence in heart failure care was thin. The analysis draws on the JROADHF-NEXT registry of patients hospitalized with acute decompensated heart failure across Japan.
The team measured how often bleeding events occurred, whether risk climbed with frailty severity, and whether a bleed predicted later death among patients receiving antiplatelet or anticoagulant therapy. Answers to those three questions shape everyday prescribing, where doctors balance clot prevention against bleeding danger in patients least able to tolerate either. Registry analyses like this one give that balancing act actual numbers instead of habit and worry.
Catalog record
| CREATOR | Taisuke Nakade, Yudai Fujimoto, Tomomi Ide, Keisuke Kida, Shouji Matsushima, Hidetaka Kaku, Nobuyuki Enzan, Masataka Ikeda, Takeshi Kitai, Tatsunori Taniguchi, Takahiro Okumura, Takeshi Tohyama, Hiroyuki Tsutsui, Yuya Matsue |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42370 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |