Cerebral cavernous malformations: epidemiology, molecular pathogenesis, diagnosis and therapy
Suyun Yu, Weiwei Zheng, Yanhong Pan, Liwenyu Chen, Jing Ma, Mengyuan Gao, Wei Zou, Yin Lu, Yang Zhao · 2026
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Description
Yu and co-authors review a brain vessel disorder made of clusters of weak, tangled vessels. These clusters can cause seizures, headaches, loss of function, or bleeding in the brain. They arise when any of three genes loses its normal function, by birth or by later change.
The review covers how common the disorder is, how it forms, and how doctors find and treat it. Hallmarks include excess vessel growth, leaky walls, and faulty cell cleanup. The authors sort what is known about each gene's role. They also track how the field's grasp has grown over past decades. No drug yet targets the root causes, so the gaps they mark matter. Their survey gives clinicians and labs a single map of the field.
Catalog record
| CREATOR | Suyun Yu, Weiwei Zheng, Yanhong Pan, Liwenyu Chen, Jing Ma, Mengyuan Gao, Wei Zou, Yin Lu, Yang Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 101 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |