Organelle Crosstalk: Mitochondria and Endoplasmic Reticulum in Macular Degeneration
Iffat Alam, Ayeshah Hussain, Devendra K. Agrawal · 2026
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Description
Iffat Alam, Ayeshah Hussain, and Devendra Agrawal review how two cell compartments talk to each other in the commonest cause of sight loss in older adults. The disease slowly kills the support layer at the back of the eye. Its power units are known to fail, but the role of its protein-folding compartment is less explored.
The two compartments touch at special contact zones. Those zones run calcium signals, shape the power units, and help decide cell death. When the zones fail, harmful oxygen byproducts build up, calcium floods, and inflammation switches on. The review gathers findings on this cross-talk in the eye's support cells. It frames the contact zones as possible drug targets. Most current care slows only the late, wet form of the disease.
Catalog record
| CREATOR | Iffat Alam, Ayeshah Hussain, Devendra K. Agrawal |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 18 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |