Type 2 diabetes-associated gut microbial composition and short chain fatty acids differ across the epidemiologic transition in African origin populations
Larske M Soepnel, Julianne A Jorgensen, Luke Hannan, Candice Choo-Kang, Asanda Mtintsilana, Gertrude Ecklu-Mensah, Jack A Gilbert, Kweku Bedu-Addo, Terrence E Forrester, Pascal Bovet, Bharathi Viswanathan, Estelle V Lambert · 2026
Read Type 2 diabetes-associated gut microbial composition and short chain fatty acids differ across the epidemiologic transition in African origin populations by Larske M Soepnel, Julianne A Jorgensen, Luke Hannan, Candice Choo-Kang, Asanda Mtintsilana, Gertrude Ecklu-Mensah, Jack A Gilbert, Kweku Bedu-Addo, Terrence E Forrester, Pascal Bovet, Bharathi Viswanathan, Estelle V Lambert (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13652081.txt.
Description
Larske Soepnel and colleagues compare gut microbes and type 2 diabetes across five populations of African origin. Their study covers middle-aged adults in Ghana, South Africa, Jamaica, Seychelles, and the United States. Places that sit at very different points in the shift from fiber-rich traditional diets to processed foods. Stool samples were sequenced and tested for short chain fatty acids, alongside blood measures of glucose and insulin.
Microbial diversity and fatty acid levels ran highest in Ghana and lowest in the United States. Diabetes came with lower diversity overall, though that link faded once location was taken into account, and certain microbes stayed tied to the disease after adjustment. The results show that findings from Western cohorts do not transfer neatly, and that diet transition leaves a measurable mark on the gut.
Catalog record
| CREATOR | Larske M Soepnel, Julianne A Jorgensen, Luke Hannan, Candice Choo-Kang, Asanda Mtintsilana, Gertrude Ecklu-Mensah, Jack A Gilbert, Kweku Bedu-Addo, Terrence E Forrester, Pascal Bovet, Bharathi Viswanathan, Estelle V Lambert |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |