Catalytic C(sp2)–F Bond Gallylation via Dynamic Ni–Ga Cooperativity
Christoph Riesinger, Mark R. Crimmin · 2026
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Description
Christoph Riesinger and one colleague report a two-metal catalyst that swaps fluorine for gallium on aromatic rings, attacking the strongest single bond in organic chemistry. Carbon-fluorine bonds give fluorinated compounds their prized stability in drugs and materials, and that same strength makes them miserable to transform afterward.
Their catalyst pairs nickel with gallium without any supporting ligand holding them together, an unusual freedom that lets the assembly switch between two-metal and three-metal forms as the reaction cycle demands. Spectroscopy, kinetics, and computation, together with isolated intermediates, identified the resting state of the catalyst and the slow step that breaks the carbon-fluorine bond. The payoff is scope: electron-rich fluoroarenes that refused earlier gallylation chemistry now react. The authors credit the dynamic cooperation between the two metals for capabilities no single-metal system had shown.
Catalog record
| CREATOR | Christoph Riesinger, Mark R. Crimmin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |