The mechanistic role of adipokine imbalance in airway inflammation, hyperresponsiveness, and remodeling in obesity-related asthma
Mingyue Ren, Guihua Song, Bingxue Zhang, Mengmeng Sun, Suping Yu, Yan Zhang · 2026
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Description
Mingyue Ren and five colleagues review how fat-derived hormones may drive obesity-related asthma, a stubborn form of the disease with poor control, frequent attacks, and weak response to standard steroids. Body weight pressing on the chest explains some symptoms, so the authors focus on a hormonal axis: too much leptin and too little adiponectin, two signals secreted by fat tissue.
Evidence from population studies, animals, and airway cells links this imbalance to three connected harms. Immune activation deepens, partly through a fired-up inflammatory complex in macrophages. Airway twitchiness rises through inflammatory, neural, and muscle pathways. Remodeling follows, as repair fails, smooth muscle multiplies, fat around the airways talks directly to them, and scar-like matrix accumulates. Their model moves from systemic hormone signals early to local fat-airway chatter later, ending in fixed structural change, and they propose the hormones as sorting markers for tailored treatment trials.
Catalog record
| CREATOR | Mingyue Ren, Guihua Song, Bingxue Zhang, Mengmeng Sun, Suping Yu, Yan Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |