Beyond molecular classification: integrating signaling, subcellular, and immune reprogramming in endometrial cancer
Miłosz Pietrus, Marcin Waligóra, Maciej W. Socha, Klaudia Skrzypek, Monika Kabzinska-Turek, Rene Laky, Iwona Gawron · 2026
Read Beyond molecular classification: integrating signaling, subcellular, and immune reprogramming in endometrial cancer by Miłosz Pietrus, Marcin Waligóra, Maciej W. Socha, Klaudia Skrzypek, Monika Kabzinska-Turek, Rene Laky, Iwona Gawron (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13650745.txt.
Description
Miłosz Pietrus and six co-authors argue that endometrial cancer, the commonest gynecological cancer in wealthy countries, needs a wider lens than its four famous molecular subtypes. That classification transformed care and lately enabled combined chemotherapy and immunotherapy as a first-line standard, yet survival for aggressive disease still lags and tumors differ in far more than their mutations.
The review layers in misrouted developmental signaling, proteins found in the wrong cell compartments, chemical gene marks, stem-cell traits, and the immune landscape inside tumors. It surveys small regulatory RNAs in tissue and blood that separate grades and forecast outcomes, counts of infiltrating immune cells, and the pattern of immune receptors as a newer marker. Emerging tools include tumor DNA in blood for spotting leftover disease, single-cell and spatial mapping, and AI-assisted pathology. Their integrated model is meant to sharpen prognosis and treatment matching.
Catalog record
| CREATOR | Miłosz Pietrus, Marcin Waligóra, Maciej W. Socha, Klaudia Skrzypek, Monika Kabzinska-Turek, Rene Laky, Iwona Gawron |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |