Berberine suppresses mechanical stretch-induced apoptosis and proliferation in vascular smooth muscle cells via ROS/PDI/Drp1 signaling pathway
Ning Lin, Haiming Niu, Xiaodong Cai, Shuying Liu, Miaolian Chen, Conghui Yu, Yingzhang Cai, Linli Wang · 2026
Read Berberine suppresses mechanical stretch-induced apoptosis and proliferation in vascular smooth muscle cells via ROS/PDI/Drp1 signaling pathway by Ning Lin, Haiming Niu, Xiaodong Cai, Shuying Liu, Miaolian Chen, Conghui Yu, Yingzhang Cai, Linli Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13649513.txt.
Description
Ning Lin and seven colleagues studied why blood vessel muscle cells react in split ways to stretch: some die off, while others multiply. Both paths harm artery health under high blood pressure. The team stretched the cells in the lab and traced how a scaffold protein inside each cell set its fate.
Cells with distinct scaffold levels made distinct amounts of a harmful oxygen signal in their power units. That signal switched on both a growth path and a death path through one shared chain. A plant compound, berberine, calmed both paths by damping the chain's first link. Treated cells showed less growth and less death under stretch. The authors pitch the compound as a lead for stretch-linked artery disease.
Catalog record
| CREATOR | Ning Lin, Haiming Niu, Xiaodong Cai, Shuying Liu, Miaolian Chen, Conghui Yu, Yingzhang Cai, Linli Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |