Distinct systemic metabolic phenotypes associated with blood culture positivity and bacterial etiology in community-acquired pneumonia (CAP)
Mohammad Mehdi Banoei, Sachin Yende, Derek C Angus, Brent W Winston · 2026
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Description
Mohammad Mehdi Banoei and three colleagues tested whether blood chemistry at hospital entry can show if pneumonia germs have reached the blood. Blood cultures are slow and often change little in care. The team profiled blood plasma from 80 patients with germ-caused pneumonia caught outside hospital, half with positive cultures and half matched without.
Clear chemical patterns split the two groups on all three lab platforms. Blood with germs showed more of some waste and sugar markers and less of key amino acids and fats, a sign of shifted energy use. Patterns also split one common germ, the pneumococcus, from other causes in early checks. The authors call for tests in fresh groups of patients.
Catalog record
| CREATOR | Mohammad Mehdi Banoei, Sachin Yende, Derek C Angus, Brent W Winston |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |