hTERT associates with Rab7A to enhance autophagy and rescue oxLDL induced endothelial dysfunction
Praveen Machiraju, Rajesh Srinivas, Rohit Shetty, Rupak Mukhopadhyay, Stephane Heymans, Arkasubhra Ghosh · 2026
Read hTERT associates with Rab7A to enhance autophagy and rescue oxLDL induced endothelial dysfunction by Praveen Machiraju, Rajesh Srinivas, Rohit Shetty, Rupak Mukhopadhyay, Stephane Heymans, Arkasubhra Ghosh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13649479.txt.
Description
Praveen Machiraju and five colleagues found a fresh role for a protein best known for guarding chromosome ends: it helps blood vessel cells clean up waste and resist harm from oxidised cholesterol. Such harm drives artery disease, and the self-cleaning process often falters in sick vessels. The team worked with human vein cells dosed with oxidised cholesterol.
The toxic fat lowered the protein's levels and raised a sticky marker of vessel distress. Adding the protein back cut fat build-up, eased cell sticking, and restored the vessel wall's seal. Blocking it did the reverse. The protein paired with a partner that steers waste sacs to disposal, and the pair grew closer under fat stress. The authors see this as a new shield for vessel health.
Catalog record
| CREATOR | Praveen Machiraju, Rajesh Srinivas, Rohit Shetty, Rupak Mukhopadhyay, Stephane Heymans, Arkasubhra Ghosh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |