Skin Metastasis of an Occult Primary Bronchopulmonary Disease: A Case Report and Literature Review

Alexander Muacevic, John R Adler, Hadil Rafi, Soufiane Berhili, Ahmed BenSghier, Mohamed Moukhlissi, Loubna Mezouar · 2026

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Description

Alexander Muacevic and six colleagues report a seventy-eight-year-old former heavy smoker whose fast-growing chest wall nodule turned out to be skin spread from a hidden lung cancer. Skin metastases are uncommon and usually signal advanced disease, and here they were the very first sign.

Biopsy showed a poorly differentiated glandular cancer, but two stains normally pointing to lung origin came back negative, complicating the search. Chest imaging then found a tumour in the right lower lobe, confirmed by airway biopsy, with spread already in brain, adrenal glands, and bone. A tumour board chose brain radiotherapy with palliative chemotherapy, and disease stayed stable at six months. The authors stress integrated diagnosis over single stains.

Catalog record

CREATORAlexander Muacevic, John R Adler, Hadil Rafi, Soufiane Berhili, Ahmed BenSghier, Mohamed Moukhlissi, Loubna Mezouar
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE16 KB
LICENSEhttps://creativecommons.org/licenses/by/4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/article/MED/PMC13649164

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