Early emergence of contractility and mechanotransduction during human megakaryopoiesis
Oleg V Kim, Rustem I Litvinov, Deborah L French, Lawrence F Brass, Giulia Pavani, John W Weisel · 2026
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Description
Oleg V. Kim and five colleagues find when platelet parent cells first learn to squeeze blood clots. Platelets are the cell shards that seal wounds. Their parents, called megakaryocytes, grow in the marrow and shed them into the blood. The team raised these parents from human stem cells in steps.
Plain stem cells could not squeeze at all. Blood starter cells already pulled on clot strands when roused, though weakly. The pull came from the subset pledged to the platelet line, and wiping that subset out erased the pull. Grown parents pulled far harder and faster. One surface switch, flipped on by the pledge, drove the act. The team calls squeeze power an early badge of the line.
Catalog record
| CREATOR | Oleg V Kim, Rustem I Litvinov, Deborah L French, Lawrence F Brass, Giulia Pavani, John W Weisel |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |