Lysophosphatidylserine Nanoparticles Induce Oral Tolerance Independent of TIM-4 and Canonical PS Processing
Edwin J Ovalle, Vincent Chak, Elizabeth A Wohlfert, Sathy Balu-Iyer, Jason G Kay · 2026
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Description
Edwin J. Ovalle and four colleagues test whether a receptor called TIM-4 is required for oral tolerance induced by nanoparticles carrying lysophosphatidylserine, a fat that mimics signals from dying cells. Such particles aim to teach the immune system to accept therapeutic proteins instead of making antibodies against them.
Mice lacking TIM-4 developed tolerance to a model protein delivered by mouth just as well as normal mice, so that receptor is not essential here. Imaging also showed the single-chain particles engaging and travelling through immune cells differently from their double-chain cousins. The authors conclude that chain number, not just the shared head group, shapes how these tolerising particles work.
Catalog record
| CREATOR | Edwin J Ovalle, Vincent Chak, Elizabeth A Wohlfert, Sathy Balu-Iyer, Jason G Kay |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |