Associations of plasma metabolites with protein biomarkers linked to Alzheimer’s disease pathology in the Rotterdam Study
Midas M Kuilman, Shahzad Ahmad, Amos C Pomp, Frank J Wolters, Rima Kaddurah-Daouk, M Arfan Ikram, Mohsen Ghanbari · 2026
Read Associations of plasma metabolites with protein biomarkers linked to Alzheimer’s disease pathology in the Rotterdam Study by Midas M Kuilman, Shahzad Ahmad, Amos C Pomp, Frank J Wolters, Rima Kaddurah-Daouk, M Arfan Ikram, Mohsen Ghanbari (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13647584.txt.
Description
Midas M Kuilman and six colleagues hunt for blood chemicals that track Alzheimer's disease protein markers in the Rotterdam population study, in a 2026 paper. More than three thousand participants gave blood for the disease proteins, and two platforms measured hundreds of metabolites in overlapping subgroups. Models adjusted for lifestyle, demographics, and genetic risk, with splits by sex and by the APOE gene. Sensitivity checks removed people with dementia, stroke, or weak kidneys.
Fat-carrying particles rich in triglycerides tracked upward with both amyloid proteins, strongest in the smallest particle class. Protective HDL fractions moved the other way. An inflammation marker and a kidney marker rose with every disease protein, while albumin fell as damage markers rose. Certain one-carbon chemistry products also climbed across the board. The authors say the pattern sketches the metabolic backdrop against which brain disease unfolds, and may yield risk markers cheaper than brain scans.
Catalog record
| CREATOR | Midas M Kuilman, Shahzad Ahmad, Amos C Pomp, Frank J Wolters, Rima Kaddurah-Daouk, M Arfan Ikram, Mohsen Ghanbari |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43985 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |