Thalamic quantitative susceptibility mapping and susceptibility source separation: a critical narrative review of evidence and interpretation
Sadegh Ghaderi, Maria Agnese Pirozzi, Minoo Sharbafshaaer, Francesca Trojsi, Sana Mohammadi, Seyed-Mohammad Fereshtehnejad · 2026
Read Thalamic quantitative susceptibility mapping and susceptibility source separation: a critical narrative review of evidence and interpretation by Sadegh Ghaderi, Maria Agnese Pirozzi, Minoo Sharbafshaaer, Francesca Trojsi, Sana Mohammadi, Seyed-Mohammad Fereshtehnejad (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13647462.txt.
Description
Sadegh Ghaderi and five colleagues critically review brain imaging of the thalamus, the brain's relay hub, using a magnetic method that can hide as much as it reveals. The standard map measures only net magnetism, so iron-like and myelin-like contributions can cancel out. Newer separation methods split the signal into its two opposing parts. The review weighs human evidence in aging and disease, keeping animal and methods work in a separate ledger.
Reduced thalamic magnetism appears again and again in multiple sclerosis, while findings in Alzheimer's and Parkinson's diseases stay inconsistent. Method differences explain some clashes, though not all. The separated components may expose biology the net map conceals, yet they rest on modeling assumptions and lack tissue proof. The authors conclude these measures remain research tools, awaiting standard methods, validation, and thresholds that would make them clinically useful.
Catalog record
| CREATOR | Sadegh Ghaderi, Maria Agnese Pirozzi, Minoo Sharbafshaaer, Francesca Trojsi, Sana Mohammadi, Seyed-Mohammad Fereshtehnejad |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |