Fast-Dissolving and Highly Soluble Dasatinib Multicomponent Crystals Efficiently Inhibit Leukemia Cell Viability
Luan F Diniz, Luiz C G Diógenes, Paulo S Carvalho Jr, Ezequiel A D Junior, Alexia D Nascimento, Maria E Cortés, Rubén Dario Sinisterra, Renata Diniz, Christian Fernandes · 2026
Read Fast-Dissolving and Highly Soluble Dasatinib Multicomponent Crystals Efficiently Inhibit Leukemia Cell Viability by Luan F Diniz, Luiz C G Diógenes, Paulo S Carvalho Jr, Ezequiel A D Junior, Alexia D Nascimento, Maria E Cortés, Rubén Dario Sinisterra, Renata Diniz, Christian Fernandes (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13647392.txt.
Description
Luan F Diniz and eight colleagues redesign the leukemia drug dasatinib into new crystal forms that dissolve far better in water. The drug works against chronic myelogenous leukemia, yet its poor, pH-dependent solubility limits how much the body can absorb. The team grew two novel salt forms by pairing the drug with maleic and fumaric acids. A full battery of X-ray, spectroscopic, and thermal tests confirmed the new structures.
Both forms dissolved dramatically better than the parent drug, with solubility gains reported up to roughly fifteen hundred fold in buffered water and far faster dissolving speeds. The new crystals also killed leukemia cells more strongly and more selectively in lab tests. The authors present crystal salt engineering as a practical route to rescue effective drugs whose weakness is physical rather than pharmacological. Better absorption could eventually mean more reliable dosing for patients.
Catalog record
| CREATOR | Luan F Diniz, Luiz C G Diógenes, Paulo S Carvalho Jr, Ezequiel A D Junior, Alexia D Nascimento, Maria E Cortés, Rubén Dario Sinisterra, Renata Diniz, Christian Fernandes |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| LICENSE | This article is licensed under CC-BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |