Lower 24-hour urinary 6-sulfatoxymelatonin and exploratory bile-acid and microbiome associations in adults with dyslipidemia: a prospectively enrolled cross-sectional study
Alexandre Tavartkiladze, Levan Tavartkiladze, Russel J. Reiter, Michel Burnier, Engin Ulukaya, Gaiane Simonia, Dinara Kasradze, Pirdara Nozadze, Pati Revazishvili, Irine Andronikashvili, Maia Maisuradze · 2026
Read Lower 24-hour urinary 6-sulfatoxymelatonin and exploratory bile-acid and microbiome associations in adults with dyslipidemia: a prospectively enrolled cross-sectional study by Alexandre Tavartkiladze, Levan Tavartkiladze, Russel J. Reiter, Michel Burnier, Engin Ulukaya, Gaiane Simonia, Dinara Kasradze, Pirdara Nozadze, Pati Revazishvili, Irine Andronikashvili, Maia Maisuradze (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13647349.txt.
Description
Alexandre Tavartkiladze and ten colleagues test whether low output of a sleep hormone's breakdown product tracks with unhealthy blood fats in adults with dyslipidemia. The product, measured in urine over a full day, reflects melatonin made the night before. Five hundred seventy-seven adults at a Tbilisi institute each gave three separate day-long urine collections between 2020 and 2025. Blood fats, inflammation, bile signals, and gut microbes were measured alongside, with a leaner comparison group used only descriptively.
Lower hormone output went with higher harmful LDL cholesterol, higher triglycerides, more inflammation, and lower protective HDL cholesterol. A bile-related signal ran high in most participants and also climbed as the hormone fell. Several gut microbe groups rose with higher hormone output. The authors keep the analysis exploratory and refuse causal claims from a single snapshot. Still, the pattern ties sleep chemistry to fat and inflammation inviting follow-up studies.
Catalog record
| CREATOR | Alexandre Tavartkiladze, Levan Tavartkiladze, Russel J. Reiter, Michel Burnier, Engin Ulukaya, Gaiane Simonia, Dinara Kasradze, Pirdara Nozadze, Pati Revazishvili, Irine Andronikashvili, Maia Maisuradze |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |