MHCXGraph: a graph-based approach to detecting T-cell receptor cross-reactivity
Carlos D M S Simões, Rocío L B R Maidana, Samuel C de Assis, João V S Guerra, Helder V Ribeiro-Filho · 2026
Read MHCXGraph: a graph-based approach to detecting T-cell receptor cross-reactivity by Carlos D M S Simões, Rocío L B R Maidana, Samuel C de Assis, João V S Guerra, Helder V Ribeiro-Filho (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13647279.txt.
Description
Simões and co-authors present a graph-based tool that spots where immune receptors might cross-react. A T cell receptor reads small protein bits shown on cell surfaces. One receptor can answer several bits, which helps coverage but risks harm in cell therapies.
Their tool turns the shown bits and their holders into a network. It hunts for shared, immune-relevant regions across many such structures. It runs in three modes: many-way, pairwise, and screening, each with settings the user can tune. Results come through a friendly interface that shows its reasoning. Tests on several cases checked its accuracy. A clear cross-reaction warning could make engineered cell therapies safer. It may also explain some autoimmune flares.
Catalog record
| CREATOR | Carlos D M S Simões, Rocío L B R Maidana, Samuel C de Assis, João V S Guerra, Helder V Ribeiro-Filho |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |