Malignant epithelial diversification and inflammatory neutrophil remodeling define a transitional stage between tumor cell dissemination and overt metastatic outgrowth in breast cancer
Rajneesh Pathania, Brian N. Papas, Justin Kosak, Senthilkumar Cinghu, Dhirendra Kumar, Brian J. Deskin, Andrew J. Oldfield, Anuj Pandey, Andrew J. Siladi, Saurabh Tiwari, Marie A. Iannone, Maria I. Sifre, Carl D. Bortner, Xin Xu, Rajasekaran Mahalingam, Gagan Deep, Rahul S. Shinde, Sivareddy Kotla, · 2026
Read Malignant epithelial diversification and inflammatory neutrophil remodeling define a transitional stage between tumor cell dissemination and overt metastatic outgrowth in breast cancer by Rajneesh Pathania, Brian N. Papas, Justin Kosak, Senthilkumar Cinghu, Dhirendra Kumar, Brian J. Deskin, Andrew J. Oldfield, Anuj Pandey, Andrew J. Siladi, Saurabh Tiwari, Marie A. Iannone, Maria I. Sifre, Carl D. Bortner, Xin Xu, Rajasekaran Mahalingam, Gagan Deep, Rahul S. Shinde, Sivareddy Kotla, (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13647235.txt.
Description
Rajneesh Pathania and co-authors catch breast cancer in the act of spread, at a stage most labs miss, in a study from 2026. Loose cancer cells land in fresh organs, but most die or sleep; few grow into full spread. What tips the scale in that brief phase was a blank.
In a mouse whose breast tumors spread on their own, the team read lungs that held loose cells but no lumps. A marked set of roam cells stood out, rich in states for bend, stress, and stealth. A ripe white cell state grew in the same lungs, primed to chew tissue and feed swell. Both marks show up in human spread cases and track with worse paths. The phase gives drug teams a fresh span to strike.
Catalog record
| CREATOR | Rajneesh Pathania, Brian N. Papas, Justin Kosak, Senthilkumar Cinghu, Dhirendra Kumar, Brian J. Deskin, Andrew J. Oldfield, Anuj Pandey, Andrew J. Siladi, Saurabh Tiwari, Marie A. Iannone, Maria I. Sifre, Carl D. Bortner, Xin Xu, Rajasekaran Mahalingam, Gagan Deep, Rahul S. Shinde, Sivareddy Kotla, |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |