Depression and shortened survival in patients with cancer: a neuroimmune framework for bidirectional pathogenesis and therapeutic interception
Jiang-Bo Li, Wei Rong, Bin-Hui Xiao, Fan Zhou, Li-Hong Lei, Yu-Wei Liu, Zai-Ping Wang, Sha Zhu · 2026
Read Depression and shortened survival in patients with cancer: a neuroimmune framework for bidirectional pathogenesis and therapeutic interception by Jiang-Bo Li, Wei Rong, Bin-Hui Xiao, Fan Zhou, Li-Hong Lei, Yu-Wei Liu, Zai-Ping Wang, Sha Zhu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13647133.txt.
Description
Jiang-Bo Li and seven colleagues build a framework linking depression with shorter survival in cancer patients through the body's stress and immune wiring. Depression is common in cancer and tracks with earlier death, yet the biology between mood and tumor has stayed murky. The review joins clinical, population, and lab evidence into one system. The nerve network that sets fight-or-flight tone, the hormone axis that releases stress steroids, and the immune network talk to each other in reinforcing loops.
Together, the trio can create conditions that favor tumor growth, the authors argue. They grade the support at each node and flag open fights, above all about which direction cause runs. Three patient subtypes are proposed, dominated by hormone, inflammation, or immune-killing patterns, to guide future trials. Any therapy built on the framework, they insist, stays experimental until large trials with survival endpoints test it.
Catalog record
| CREATOR | Jiang-Bo Li, Wei Rong, Bin-Hui Xiao, Fan Zhou, Li-Hong Lei, Yu-Wei Liu, Zai-Ping Wang, Sha Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |