Role of NUDT3 in skeletal myogenesis and association of regulatory genetic variants with carcass traits in pigs
Ya-Long An, Yong-Qi Yue, Yang Li, Teng-Fei Zheng, Zi-Hao Ge, Yan-Ru Yue, Rong-Rong Ding, Ji-Ying Wang, Xiao Li · 2026
Read Role of NUDT3 in skeletal myogenesis and association of regulatory genetic variants with carcass traits in pigs by Ya-Long An, Yong-Qi Yue, Yang Li, Teng-Fei Zheng, Zi-Hao Ge, Yan-Ru Yue, Rong-Rong Ding, Ji-Ying Wang, Xiao Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13647061.txt.
Description
Ya-Long An and eight co-authors study the gene NUDT3 in pig muscle growth in this 2026 paper. Genome scans had tied the gene to lean mass in both humans and pigs, but its job in muscle building was unclear. The team silenced the gene in pig muscle satellite cells, the stem cells that repair and grow muscle. Silencing stalled the cells' division and blocked their shift into muscle fibers. Extra gene copies did the reverse.
In live mice, boosting the gene in a leg muscle raised repair cell counts after injury. Gene reads showed the gene calms the NF-κB pathway. The team then hunted gene variants that tune NUDT3 levels in pig muscle. Eight variants qualified, and one inside an enhancer also tracked with loin size in a large pig data bank. The authors name it a candidate marker for breeding leaner pigs.
Catalog record
| CREATOR | Ya-Long An, Yong-Qi Yue, Yang Li, Teng-Fei Zheng, Zi-Hao Ge, Yan-Ru Yue, Rong-Rong Ding, Ji-Ying Wang, Xiao Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |