Androgen and glucocorticoid crosstalk in granulosa cells: molecular insights into polyendocrine metabolic ovarian syndrome
Martina Pinna, Alessandra Tomaselli, Davide Ferrari, Marianna Minnetti, Daniele Gianfrilli, Elisa Giannetta, Carlotta Pozza, Andrea M Isidori, Federica Barbagallo, Riccardo Pofi · 2026
Read Androgen and glucocorticoid crosstalk in granulosa cells: molecular insights into polyendocrine metabolic ovarian syndrome by Martina Pinna, Alessandra Tomaselli, Davide Ferrari, Marianna Minnetti, Daniele Gianfrilli, Elisa Giannetta, Carlotta Pozza, Andrea M Isidori, Federica Barbagallo, Riccardo Pofi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13646784.txt.
Description
Martina Pinna and nine colleagues review how two hormone receptors talk to each other inside the ovary's granulosa cells, and how that crosstalk may drive a common hormone disorder. The disorder, newly renamed polyendocrine metabolic ovarian syndrome, brings excess male hormones, irregular ovulation, and metabolic strain. Granulosa cells nurse the egg and make hormones, and their failure sits at the disease's center. The receptors in question answer to androgens and to stress hormones.
The two receptors share stretches of DNA binding and many helper proteins, so each can bend the other's gene program. The review adds adrenal-made androgens, newly recognized as potent, that may amplify the signal further. Evidence from molecular, animal, and patient studies is woven into one testable framework. The authors propose the crosstalk as a source of biomarkers and of future treatments aimed at the mechanism rather than at symptoms alone.
Catalog record
| CREATOR | Martina Pinna, Alessandra Tomaselli, Davide Ferrari, Marianna Minnetti, Daniele Gianfrilli, Elisa Giannetta, Carlotta Pozza, Andrea M Isidori, Federica Barbagallo, Riccardo Pofi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |