Bridging radiomics and histopathology: cross-modality consistency of radiomic features from CT to micro-CT in NSCLC
Leonardo Brizzi, Chandra Bortolotto, Raffaella Fiamma Cabini, Francesca Brero, Silvia Megalizzi, Gioacchino D’Ambrosio, Marta Filibian, Roberta Gioia, Paola Falvo, Giulia Maria Stella, Olivia Maria Bottinelli, Alessandro Lascialfari, Lorenzo Preda · 2026
Read Bridging radiomics and histopathology: cross-modality consistency of radiomic features from CT to micro-CT in NSCLC by Leonardo Brizzi, Chandra Bortolotto, Raffaella Fiamma Cabini, Francesca Brero, Silvia Megalizzi, Gioacchino D’Ambrosio, Marta Filibian, Roberta Gioia, Paola Falvo, Giulia Maria Stella, Olivia Maria Bottinelli, Alessandro Lascialfari, Lorenzo Preda (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13646218.txt.
Description
Leonardo Brizzi and co-authors ask whether texture measures from medical scans stay consistent from patient scans down to microscope-like scans of removed tumours, in a 2026 study. Such measures, called radiomic features, may act as stand-ins for tumour biology, but few studies test them on micro-CT or ask if they transfer to clinical scans. Sixty lung cancer patients with scans before surgery and tissue samples were studied.
Tumour regions were traced semi-automatically on all three scan types, and ninety-three features were extracted. Standard steps such as normalisation and volume matching improved agreement, with the best results on normalised data. Four texture features stayed highly consistent across all scan types and also separated the two main cancer subtypes. The authors argue those features form a transferable signature that links micro-CT to clinical CT, ready for deeper biological studies.
Catalog record
| CREATOR | Leonardo Brizzi, Chandra Bortolotto, Raffaella Fiamma Cabini, Francesca Brero, Silvia Megalizzi, Gioacchino D’Ambrosio, Marta Filibian, Roberta Gioia, Paola Falvo, Giulia Maria Stella, Olivia Maria Bottinelli, Alessandro Lascialfari, Lorenzo Preda |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |