Thirty years later: Revisiting the glial failure hypothesis as the homeostatic organizing principle of ischemic injury
Oscar Herreras, Santiago Canals · 2026
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Description
Oscar Herreras and Santiago Canals revisit a thirty-year-old idea about stroke damage in the brain in a 2026 paper. The idea is the glial failure hypothesis, first set out three decades ago. It blames support cells, called glia, for much of the harm after ischemia. Ischemic injury still lacks one unifying mechanism today.
Astrocytes, a glial type, guard fuel, ion, and blood balance in tissue. Early glial moves may shield tissue by cutting energy demand. As glia fail, waves of cell shutdown spread and fail to stop. Tissue then tips toward fast or delayed cell death. The authors cast glial failure as the upstream cause. It links fuel loss to nerve cell injury in one chain.
Catalog record
| CREATOR | Oscar Herreras, Santiago Canals |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |