Disproportionality analysis of adverse event signals associated with seven Alzheimer’s drugs: insights from the FAERS database
Kai Liu, Xiaohu Yang, Lingti Kong · 2026
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Description
Kai Liu, Xiaohu Yang, and Lingti Kong compare side effect reporting patterns for seven Alzheimer's disease drugs in the United States reporting system FAERS. The set covers three newer antibody drugs and four older symptom drugs. Reports ran from early 2004 to mid 2026 and totaled 39,301 valid cases. Four statistical methods hunted for events reported more often than expected, with extra checks for false alarms.
Women and patients over sixty-five supplied most reports. The antibody drugs showed focused signals in nervous system events, above all a brain swelling and bleeding pattern tied to amyloid treatment, plus infusion reactions. Older drugs showed wider, body-spanning patterns, from heart and fall signals to patch-site reactions and confusion. Some signals were absent from the drug labels the team reviewed. The authors stress that reporting patterns flag questions for study, not proven harms.
Catalog record
| CREATOR | Kai Liu, Xiaohu Yang, Lingti Kong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |