Case report: Systemic T-DXd and bevacizumab plus local therapy prolongs survival in breast cancer leptomeningeal metastasis: a case series and literature review
Junmei Zhang, Xuezheng Wang, Tiezhu Li, Luyao Yang, Yan Xue · 2026
Read Case report: Systemic T-DXd and bevacizumab plus local therapy prolongs survival in breast cancer leptomeningeal metastasis: a case series and literature review by Junmei Zhang, Xuezheng Wang, Tiezhu Li, Luyao Yang, Yan Xue (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13645690.txt.
Description
Junmei Zhang and four colleagues describe seven breast cancer patients whose cancer spread to the membranes around the brain and spinal cord, a complication with a very poor outlook. All seven received an antibody-drug treatment called trastuzumab deruxtecan together with whole-brain radiation. Four also received a blood-vessel drug and chemotherapy placed into the spinal fluid. The paper pairs the case series with a review of the wider literature.
In the four patients who got the fuller combination, brain and nerve symptoms eased fast, and survival ran longer than older reports suggest for this condition. No severe or fatal side effects appeared in the group. The authors are careful to frame this as early experience from very few patients. Still, the cases give other cancer teams a concrete regimen to consider where no standard treatment exists.
Catalog record
| CREATOR | Junmei Zhang, Xuezheng Wang, Tiezhu Li, Luyao Yang, Yan Xue |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |