Sph-mediated mtDNA release and autophagy-dependent ferroptosis contribute to Staphylococcus aureus-induced mastitis
Yunfei Wei, Xinyu Zhao, Ziyi Yin, Yanmin Zhang, Yaxin Zhai, Baihe Zhan, Yeling Wang, Jiakang He, Jianfeng Wang, Xuming Deng, Lei Xu, Haihua Feng · 2026
Read Sph-mediated mtDNA release and autophagy-dependent ferroptosis contribute to Staphylococcus aureus-induced mastitis by Yunfei Wei, Xinyu Zhao, Ziyi Yin, Yanmin Zhang, Yaxin Zhai, Baihe Zhan, Yeling Wang, Jiakang He, Jianfeng Wang, Xuming Deng, Lei Xu, Haihua Feng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13645233.txt.
Description
Yunfei Wei and twelve colleagues present a study of how a Staphylococcus aureus toxin factor, Sph, drives mammary gland inflammation in mastitis, a costly disease of dairy animals. The enzyme was known to injure host cells, but its pathway to tissue damage was unclear.
Deleting the factor sharply reduced ferroptosis, an iron-linked cell death, during infection. The team traced a chain: the factor binds a mitochondrial organizer, breaks the organelle's inner folds, and spills mitochondrial DNA into the cell. A DNA sensor pathway then sends the protective enzyme GPX4 for destruction, removing the brake on ferroptosis. Blocking the factor could become a mastitis treatment strategy.
Catalog record
| CREATOR | Yunfei Wei, Xinyu Zhao, Ziyi Yin, Yanmin Zhang, Yaxin Zhai, Baihe Zhan, Yeling Wang, Jiakang He, Jianfeng Wang, Xuming Deng, Lei Xu, Haihua Feng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |