Mapping the Tissue Architecture and Endothelial‐PEC Network in HAML Using Single‐Cell and Spatial Transcriptomics
Xinyang Liu, Yang Guo, Xuehong Tie, Yu Liu, Fuyu Li, Jingkai Liu, Xiaohang Sun, Jiajun Zhao, Feng Geng, Yingjian Liang · 2026
Read Mapping the Tissue Architecture and Endothelial‐PEC Network in HAML Using Single‐Cell and Spatial Transcriptomics by Xinyang Liu, Yang Guo, Xuehong Tie, Yu Liu, Fuyu Li, Jingkai Liu, Xiaohang Sun, Jiajun Zhao, Feng Geng, Yingjian Liang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13644742.txt.
Description
Liu and co-authors map the inner layout of a rare liver tumor using gene reads from single cells and from set spots in tissue. The tumor grows from a family of cells that wrap blood vessels. Its liver form is far rarer than its kidney cousin, and how it grows is poorly known.
The team studied tissue from three cases not tied to inherited disease. They sorted the tumor cells into groups with unlike jobs and placed each group in its tissue niche. One tumor group looked much like vessel-lining cells, hinting it may arise from them. A signal passed from vessel cells to tumor cells stood out as a growth driver. Blocking that signal could be a drug path. The map gives future studies a base to build on.
Catalog record
| CREATOR | Xinyang Liu, Yang Guo, Xuehong Tie, Yu Liu, Fuyu Li, Jingkai Liu, Xiaohang Sun, Jiajun Zhao, Feng Geng, Yingjian Liang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |