Immunosenescence in systemic and multi-organ aging: mechanisms, inter-organ crosstalk, and translational opportunities
Zhi-Guo Wu, Qiang-Qiang Zhao, Sheng-Rong Lin, Jia-Ying Lei, Cheng-Jun Yang, Shu-Ning Sun, Zhong-Qi Yang, Shi-Hao Ni, Xing-Ling Chen, Lu Lu · 2026
Read Immunosenescence in systemic and multi-organ aging: mechanisms, inter-organ crosstalk, and translational opportunities by Zhi-Guo Wu, Qiang-Qiang Zhao, Sheng-Rong Lin, Jia-Ying Lei, Cheng-Jun Yang, Shu-Ning Sun, Zhong-Qi Yang, Shi-Hao Ni, Xing-Ling Chen, Lu Lu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13642257.txt.
Description
Zhi-Guo Wu and nine colleagues present a 2026 review of immunosenescence, the aging of the immune system, as a driver and mirror of decline across many organs at once. Aging increasingly looks like a whole-body process rather than separate organ failures.
The review gathers mechanisms inside immune niches, two-way signaling between immune cells and organs, and shifts in both innate and adaptive arms. It weighs biomarker panels for measuring immune age and discusses senolytic and senomorphic drugs that clear or calm worn-out cells. Limits include mixed contexts and unsettled cause-and-effect. The authors frame the immune system as a lever for extending healthy years.
Catalog record
| CREATOR | Zhi-Guo Wu, Qiang-Qiang Zhao, Sheng-Rong Lin, Jia-Ying Lei, Cheng-Jun Yang, Shu-Ning Sun, Zhong-Qi Yang, Shi-Hao Ni, Xing-Ling Chen, Lu Lu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 109536 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |