Intravenous megadose sodium ascorbate normalises elevations in intracranial pressure and restores pressor responsiveness to norepinephrine in ovine Gram-negative sepsis
Maya S Bishop, Ruslan V Pustovit, Alemayehu H Jufar, Darius J R Lane, Clive N May, Scott Ayton, Mark P Plummer, Connie P C Ow, Yugeesh R Lankadeva · 2026
Read Intravenous megadose sodium ascorbate normalises elevations in intracranial pressure and restores pressor responsiveness to norepinephrine in ovine Gram-negative sepsis by Maya S Bishop, Ruslan V Pustovit, Alemayehu H Jufar, Darius J R Lane, Clive N May, Scott Ayton, Mark P Plummer, Connie P C Ow, Yugeesh R Lankadeva (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13642030.txt.
Description
Maya S Bishop and eight colleagues present a 2026 sheep study of megadose vitamin C salt, sodium ascorbate, for brain pressure problems during sepsis. Severe infection often raises pressure inside the skull and dulls the response to blood pressure drugs, yet no treatment targets that brain dysfunction directly.
Sheep received live Escherichia coli infusions until sepsis developed, then either ascorbate or a matched placebo for seven hours. The treated animals' skull pressure returned to normal, blood pressure improved, and responsiveness to norepinephrine was fully restored, while placebo animals stayed impaired. The authors offer the results as first evidence for this approach.
Catalog record
| CREATOR | Maya S Bishop, Ruslan V Pustovit, Alemayehu H Jufar, Darius J R Lane, Clive N May, Scott Ayton, Mark P Plummer, Connie P C Ow, Yugeesh R Lankadeva |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42678 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |