Radiobiological comparison of holmium-166 and yttrium-90 for hepatocellular carcinoma treatment in vitro
Justine Perrin, Carolline Ntihabose, Tijmen H. de Wolf, Duschka Kleijn, Erik de Blois, Mark Konijnenberg, Antonia Denkova, Julie Nonnekens · 2026
Read Radiobiological comparison of holmium-166 and yttrium-90 for hepatocellular carcinoma treatment in vitro by Justine Perrin, Carolline Ntihabose, Tijmen H. de Wolf, Duschka Kleijn, Erik de Blois, Mark Konijnenberg, Antonia Denkova, Julie Nonnekens (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13641249.txt.
Description
Justine Perrin led a 2026 laboratory comparison of two radioactive microsphere agents for liver cancer radioembolization: holmium-166 and yttrium-90. Both deliver beta radiation to tumors through the arteries, but their biological effectiveness had never been directly compared, leaving isotope choice uninformed by biology. The team exposed three human liver cancer cell lines to equal absorbed doses of 1.5 or 2.5 gray over twenty-four hours, tracking survival and DNA damage.
Both agents cut survival in a dose-dependent way across all cell lines, with only a modest, non-significant trend toward greater toxicity from holmium-166. Holmium-166 produced fewer but larger DNA damage spots at earlier times, hinting at subtle differences in damage complexity or repair speed. At equal dose, the agents proved comparably toxic in dishes. Clinicians get a practical steer: injected activity, microsphere makeup, and distribution likely matter more than isotope choice alone.
Catalog record
| CREATOR | Justine Perrin, Carolline Ntihabose, Tijmen H. de Wolf, Duschka Kleijn, Erik de Blois, Mark Konijnenberg, Antonia Denkova, Julie Nonnekens |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |