Comprehensive somatic profiling of gastroenteropancreatic neuroendocrine neoplasms
Chirayu Mohindroo, Parul Agarwal, Valerie Lee, Jin He, Robert Anders, Katherine Bever, Daniel Laheru, Ana De Jesus-Acosta · 2026
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Description
Chirayu Mohindroo and co-authors profile gene faults in a rare group of cancers of the gut and pancreas. Their 2026 study covers one hundred eleven patients treated at Johns Hopkins Hospital between 2020 and 2022. These neuroendocrine neoplasms vary widely, and their response to treatment is hard to predict.
The team read tumor samples with next-generation sequencing and checked faults against three cancer databases. About seventy-nine percent of tumors carried a harmful or likely harmful change. The most common faults hit TP53 and MEN1, with smaller shares in genes that reshape chromatin. The authors also note a small group with faults more often seen in blood cancers, and they link patterns to survival.
Catalog record
| CREATOR | Chirayu Mohindroo, Parul Agarwal, Valerie Lee, Jin He, Robert Anders, Katherine Bever, Daniel Laheru, Ana De Jesus-Acosta |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |