Circulating matrix GLA protein during puberty in healthy and central precocious puberty children
Maria Bentz Damholt, Stine A Holmboe, Jørgen Holm Petersen, Martin Blomberg Jensen, Anders Juul, Li Juel Mortensen · 2026
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Description
Maria Bentz Damholt and co-authors measure a bone-related protein in children going through puberty in a 2026 study. The protein, called matrix GLA protein, helps control where minerals settle as bone forms. The years around puberty are when children grow fast and build much of their bone mass, so tracking the protein then may reveal how bones mature.
The team followed 111 healthy Danish children aged six to fifteen, plus fifteen girls whose puberty came early. Blood levels of the inactive form of the protein rose with age and puberty stage in both sexes. In boys the level fell again from mid-puberty. Girls with early puberty had lower levels than matched healthy girls. Treatment that paused puberty raised the level again.
Catalog record
| CREATOR | Maria Bentz Damholt, Stine A Holmboe, Jørgen Holm Petersen, Martin Blomberg Jensen, Anders Juul, Li Juel Mortensen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |