Tandem duplication upstream of HSF5 associates with transcript remodeling and triple-comb morphology in chickens
Xun-He Huang, Zhi-Feng Zhang, Zhi-Peng Zhong, Zhuo-Xian Weng, Yong-Jie Xu, Guo-Hao Zhong, Wei-Na Li, Qing Wang, Bing-Wang Du, Min-Sheng Peng, Cheng Ma · 2026
Read Tandem duplication upstream of HSF5 associates with transcript remodeling and triple-comb morphology in chickens by Xun-He Huang, Zhi-Feng Zhang, Zhi-Peng Zhong, Zhuo-Xian Weng, Yong-Jie Xu, Guo-Hao Zhong, Wei-Na Li, Qing Wang, Bing-Wang Du, Min-Sheng Peng, Cheng Ma (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13639972.txt.
Description
Xun-He Huang and ten colleagues present a genetics study of the triple comb in chickens, a breed trait whose cause was unknown. Working with Wuhua Yellow chickens, the team combined population genomics, association mapping, long-read sequencing, and embryo gene data.
They pinpointed a duplicated stretch of DNA, about fifteen thousand letters long, sitting just before a gene called HSF5. Embryos showed no overall rise in that gene's output, yet parts of it were read more heavily with unusual splicing patterns. Extra copies tracked with extra comb prongs, while triple-comb crosses showed lower fertility. The work links the duplication to the trait through transcript remodeling.
Catalog record
| CREATOR | Xun-He Huang, Zhi-Feng Zhang, Zhi-Peng Zhong, Zhuo-Xian Weng, Yong-Jie Xu, Guo-Hao Zhong, Wei-Na Li, Qing Wang, Bing-Wang Du, Min-Sheng Peng, Cheng Ma |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| LICENSE | http://creativecommons.org/licenses/by/4.0/). |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |