Aptamer-guided delivery of miR-126 suppresses glioblastoma stem-like cell invasion and tumor progression
Giorgia Castellani, Mariachiara Buccarelli, Alessandra Affinito, Gabriele De Luca, Ramona Ilari, Francesca Pedini, Alessandra Di Giamberardino, Mariagiovanna Ballato, Gabriele Ricciardi, Martina Offi, Cristiana Mollinari, Nadia Felli, Alessandra Boe, Giovanna Marziali, Mauro Biffoni, Maria Caffo, Ge · 2026
Read Aptamer-guided delivery of miR-126 suppresses glioblastoma stem-like cell invasion and tumor progression by Giorgia Castellani, Mariachiara Buccarelli, Alessandra Affinito, Gabriele De Luca, Ramona Ilari, Francesca Pedini, Alessandra Di Giamberardino, Mariagiovanna Ballato, Gabriele Ricciardi, Martina Offi, Cristiana Mollinari, Nadia Felli, Alessandra Boe, Giovanna Marziali, Mauro Biffoni, Maria Caffo, Ge (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13639097.txt.
Description
Castellani and co-authors deliver a tiny tumor-fighting RNA into the stem-like cells of the deadliest brain tumor. This tumor is the most common and aggressive in adults, with median survival of fifteen to eighteen months. Its stem-like cells drive spread into nearby brain and regrowth after treatment.
The RNA they deliver normally holds tumors back, and its loss marks worse disease. Getting it into the right cells is the hard part. The team guided it with a short binding molecule that homes to the stem-like cells. In their models the delivery curbed the cells' invasion and slowed tumor growth. A guided RNA could one day pair with standard care. The work joins two tools: a homing guide and a natural brake.
Catalog record
| CREATOR | Giorgia Castellani, Mariachiara Buccarelli, Alessandra Affinito, Gabriele De Luca, Ramona Ilari, Francesca Pedini, Alessandra Di Giamberardino, Mariagiovanna Ballato, Gabriele Ricciardi, Martina Offi, Cristiana Mollinari, Nadia Felli, Alessandra Boe, Giovanna Marziali, Mauro Biffoni, Maria Caffo, Ge |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |