Sequence-specific targeting of VEGFA genomic DNA to inhibit tumor growth
Angana De, Sai Pallavi Pradeep, Paroma Deb, Ravinder Reddy Gaddam, Ajit Vikram, Raman Bahal · 2026
Read Sequence-specific targeting of VEGFA genomic DNA to inhibit tumor growth by Angana De, Sai Pallavi Pradeep, Paroma Deb, Ravinder Reddy Gaddam, Ajit Vikram, Raman Bahal (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13639093.txt.
Description
Angana De and five colleagues report a 2026 therapy study that silences the VEGFA gene directly in tumor DNA. VEGFA drives blood vessel growth in tumors and switches on when a hypoxia factor binds a control site in low-oxygen tissue.
The team built a gamma-modified peptide nucleic acid that blocks that binding site by sequence. In several solid cancer cell lines the treatment lowered VEGFA output and cell survival. In mice with triple-negative breast tumors, it slowed growth and extended survival. The authors present DNA-level targeting as a precise way to shut down a central cancer growth signal.
Catalog record
| CREATOR | Angana De, Sai Pallavi Pradeep, Paroma Deb, Ravinder Reddy Gaddam, Ajit Vikram, Raman Bahal |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71775 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |