p38 MAPK and MDT-15 mediate SKN-1-dependent metformin-induced protection against mitis group streptococci in Caenorhabditis elegans
Ali Al Hatem, Boopathi Balasubramaniam, Alissa Villhauer, Ali K Naji, Ransome van der Hoeven · 2026
Read p38 MAPK and MDT-15 mediate SKN-1-dependent metformin-induced protection against mitis group streptococci in Caenorhabditis elegans by Ali Al Hatem, Boopathi Balasubramaniam, Alissa Villhauer, Ali K Naji, Ransome van der Hoeven (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13638828.txt.
Description
Ali Al Hatem and four colleagues published a 2026 worm study on how the diabetes drug metformin guards against mouth bacteria. These germs live in the mouth and do no harm there, but they release a bleach-like chemical that can kill the tiny worm used in this work.
Worms given metformin first survived the chemical far better, and more drug meant more protection. The effect needed SKN-1, a stress switch in the worm. Two partners were also required: the p38 MAPK pathway and a helper protein called MDT-15. The authors say metformin may deserve a look as a drug against these germs.
Catalog record
| CREATOR | Ali Al Hatem, Boopathi Balasubramaniam, Alissa Villhauer, Ali K Naji, Ransome van der Hoeven |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |