Tenapanor Beyond Phosphate: Gut Sodium Transport, Stool Transit Time, and Volume Balance in Dialysis Patients
Lucas Maciel de Almeida Corrêa, Luiggi Kevin Virgino Brandão, Clara Belo Gamon Santiago, Alexandre de Assis Barbosa, Gabriel Rian Mazur, Gabriel Costa de Santana, Yan Roberth Delmiro Silva, Letícia Esteves Dante, Ivan Felipe Dutra Júnior · 2026
Read Tenapanor Beyond Phosphate: Gut Sodium Transport, Stool Transit Time, and Volume Balance in Dialysis Patients by Lucas Maciel de Almeida Corrêa, Luiggi Kevin Virgino Brandão, Clara Belo Gamon Santiago, Alexandre de Assis Barbosa, Gabriel Rian Mazur, Gabriel Costa de Santana, Yan Roberth Delmiro Silva, Letícia Esteves Dante, Ivan Felipe Dutra Júnior (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13638484.txt.
Description
Lucas Maciel de Almeida Corrêa and colleagues offer a 2026 perspective that looks beyond phosphate control for tenapanor, a gut drug approved for high phosphate in dialysis patients. Tenapanor blocks the intestinal sodium-hydrogen exchanger NHE3, lowering phosphate and gut sodium uptake. Its wider sodium and water effects remain tangled with diarrhea and dialysis prescription quirks. The authors synthesize drug, trial, dialysis physiology, and mineral-bone evidence into a framework for testing those wider effects.
They argue that tenapanor-linked diarrhea and sodium drops should be read not only as side effects but as signs of on-target sodium-water shifts. In some patients, lower sodium loading could ease thirst, curb weight gain, and cut ultrafiltration strain, while in others fluid losses could worsen low blood volume or instability during dialysis. A possible drop in fibroblast growth factor 23 remains unproven as a bridge to heart outcomes.
Catalog record
| CREATOR | Lucas Maciel de Almeida Corrêa, Luiggi Kevin Virgino Brandão, Clara Belo Gamon Santiago, Alexandre de Assis Barbosa, Gabriel Rian Mazur, Gabriel Costa de Santana, Yan Roberth Delmiro Silva, Letícia Esteves Dante, Ivan Felipe Dutra Júnior |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |