Viscosity of concentrated mRNA solutions: Implications for downstream processing
Amin Javidanbardan, Fatemeh Najafi, Ziqiao Wang, Andrew L. Zydney · 2026
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Description
Amin Javidanbardan and three colleagues published this 2026 study measuring how thick concentrated messenger RNA solutions become. Makers of mRNA medicines must concentrate their product to reach useful doses, and thick fluids fight back during filtering and filling. No published numbers existed for such solutions. The team tested two model molecules: a standard reporter mRNA and a much longer self-amplifying RNA, across a wide range of concentrations and flow speeds.
The long molecule thickened dramatically faster. At the top concentration tested, its solution ran more than ten times thicker than the shorter one's. Both fluids thinned slightly under faster flow. The team matched their data against existing physics models to understand the behavior underneath. For factory design, the message is blunt: molecular length, not just concentration, sets how hard an mRNA product will be to process, so equipment and filtration plans must budget for it early.
Catalog record
| CREATOR | Amin Javidanbardan, Fatemeh Najafi, Ziqiao Wang, Andrew L. Zydney |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27707 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |