Coumarins as modulators of protein–protein interactions: Computational insights, biological mechanisms, and translational perspectives
Yasser Fakri Mustafa · 2026
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Description
Yasser Fakri Mustafa reviews how coumarins, a family of plant compounds, might loosen or tighten the handshakes between proteins. Many diseases run through such protein partnerships. Small molecules that adjust them are prized drug leads, yet this family's role there is little mapped.
The review gathers computer-based work on the pairing: docking trials, motion simulations, network maps, and learning models. These tools predict where a coumarin might sit at a protein interface and what it would change. Some studies cross-check the predictions in lab tests. Mustafa weighs which workflows give trustworthy answers. He also marks the proof gaps that keep these leads from the clinic. The piece serves chemists scouting a cheap, flexible scaffold.
Catalog record
| CREATOR | Yasser Fakri Mustafa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 86 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |