Mapping of C5‐Blocking Monoclonal Antibodies Reveals New C5 Inhibitory Epitopes and Novel Modes of C5 Inhibition
Rebekah Sian Cooke, Kok Yung Lee, Georgina Elizabeth Menzies, Masashi Mizuno, Bryan Paul Morgan, Wioleta Milena Zelek · 2026
Read Mapping of C5‐Blocking Monoclonal Antibodies Reveals New C5 Inhibitory Epitopes and Novel Modes of C5 Inhibition by Rebekah Sian Cooke, Kok Yung Lee, Georgina Elizabeth Menzies, Masashi Mizuno, Bryan Paul Morgan, Wioleta Milena Zelek (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13636134.txt.
Description
Rebekah Sian Cooke and five colleagues published this 2026 study mapping new ways to block a key immune protein called C5. Blocking C5 already treats several rare diseases, and two antibody drugs lead the field. The team created fresh antibodies against C5 and compared them with the marketed pair. Lab tests measured binding, competition between antibodies, and whether each one stopped the protein being split into its active pieces.
Four new antibodies blocked blood-cell destruction as well as the established drugs. Competition mapping revealed four separate blocking sites on the protein. Two sites matched the known drugs, and antibodies there stopped the split and the release of an inflammatory fragment. The two new sites worked differently: the protein still split and released its fragment, yet destruction was blocked anyway. The authors say these extra modes of inhibition widen the design space for future complement drugs.
Catalog record
| CREATOR | Rebekah Sian Cooke, Kok Yung Lee, Georgina Elizabeth Menzies, Masashi Mizuno, Bryan Paul Morgan, Wioleta Milena Zelek |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |