Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance
Geraldo Aleixo Passos, Vitor Marcel Faça, Eduardo Antonio Donadi, Ana Paula Masson, Carlos Crippa Coletto, Gustavo Ronconi Roza · 2026
Read Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance by Geraldo Aleixo Passos, Vitor Marcel Faça, Eduardo Antonio Donadi, Ana Paula Masson, Carlos Crippa Coletto, Gustavo Ronconi Roza (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13636128.txt.
Description
Geraldo Aleixo Passos and five colleagues published this 2026 review of how the thymus teaches T cells not to attack the body. Deep inside the thymus, medullary epithelial cells display a vast menu of self proteins to developing T cells. Two master regulators, Aire and Fezf2, switch on thousands of tissue-specific genes in those cells. What remained murky is the step between gene activity and the actual protein fragments loaded for display.
The review gathers new tools that read those displayed fragments directly from cells. It stresses that several layers, from protein cutting to loading, can uncouple fragment display from gene activity levels. Single-cell gene maps and fragment catalogues therefore complement each other rather than substitute. Putting both together should explain why tolerance fails in selective ways in autoimmune disease. The authors also argue the combined view can guide therapies aimed at specific self targets.
Catalog record
| CREATOR | Geraldo Aleixo Passos, Vitor Marcel Faça, Eduardo Antonio Donadi, Ana Paula Masson, Carlos Crippa Coletto, Gustavo Ronconi Roza |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53895 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |